Druggist For The People

Four score and seven minutes ago (about an hour and a half) your physician brought forth, upon her desk, a new prescription, conceived in best medical practice, and dedicated to the proposition that all generics are created equal. Now we are engaged in a great civilian war, testing whether that medication, or any medication so conceived, and so dedicated, can help us long endure. And maybe we can feel good at the same time. For forty years as a pharmacist, I've been building bridges - from the doctor to those in need of important drug information - you. With respect for the listener, and from the perspective that it is better to apply a recommended course of therapy than it is to comply with an ordered course, the goal here is not to provide specific answers about your drug therapy, but rather to help you generate the questions that will that will empower you in this. Toward that end, there will be weekly podcasts, very often with guests who will be "the people".

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Druggist For The People

Low Dose Naltrexone (LDN)

September 23, 2025 • Donald Schoeff R.Ph.

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Summary: The off-label use of naltrexone for chronic pain and inflammatory conditions is built upon observing patients being weaned from high dose naltrexone for alcohol abuse disorder, as well as its experimental use in boosting the immune system of HIV patients in the 1980s. Though the long-term use of LDN for chronic pain and the other inflammatory conditions has not been established, this unique mechanism of action may, in the future, provide another proven option for those in need. Or will it? We are in the process of discovery.

Topics:

· Low Dose Naltrexone Potential Uses 02:00

· Opioid Antagonists Naloxone and Naltrexone

· Receptor Interactions: Affinity/Intrinsic Activity/Dissociation. 04:15

· Naloxone & Naltrexone Chemistry

· Antabuse 08:20

· Fooling the Body – Negative Feeback Loop 11:30

· Microglial Cells Inhibition & Anti-inflammatory actions 12:50

· Applied Science of Medicine 14:00

· LDL Risks

· Quality of Life and Risk-Benefit 17:45

Questions and comments to druggistforthepeople@gmail.com

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Donald J. Schoeff, R.Ph.

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